Veterans Health Library
Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.valproic acid and flibanserin both increase sedation.
- Reporting of adverse events is encouraged through the FDA MedWatch program.
- Healthcare providers should report syncope, severe hypotension, or liver injury.
- Post-marketing surveillance is critical for understanding rare, long-term risks.
- Drug utilization reviews track prescribing patterns and potential misuse.
- In case of suspected pregnancy, patients should contact their doctor immediately.
- Animal studies showed developmental toxicity at doses much higher than human dose.
- Lactation studies in animals showed excretion in milk; human data are lacking.
- Decision to breastfeed while on flibanserin requires weighing potential risks.
- The benefit for an individual patient must justify the potential risk to a fetus/infant.
valproic acid will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
The Clinically Proven Treatment for Low Sexual Desire
scopolamine intranasal and flibanserin both increase sedation. selegilineselegiline will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. selegiline will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. selegiline transdermal will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sirolimusflibanserin increases levels of sirolimus by P-glycoprotein (MDR1) efflux transporter.
Clinical Uses
Increase monitoring of concentrations of drugs transported by P-gp that have a narrow therapeutic index if coadministered with flibanserin.sirolimus will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sodium oxybatesodium oxybate and flibanserin both increase sedation. sodium oxybate and flibanserin both increase sedation. sparsentansparsentan will decrease the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. Sparsentan (a CYP2C19 inducer) decreases exposure of CYP2C19 substrates and reduces efficacy related to these substrates.
FDA-approved indications
sparsentan will decrease the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. St John's WortSt John's Wort will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. St John's Wort will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. CYP3A4 substrates may require dosage adjustment.stiripentol will increase the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. vinblastinevinblastine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vinblastine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
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vincristinevincristine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What other information should I know?
Consider reducing the dose of CYP2C19 substrates, if adverse reactions are experienced when administered concomitantly with stiripentol.stiripentol, flibanserin. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. sufentanil SLsufentanil SL and flibanserin both increase sedation. Risk for sedation increased if flibanserin is coadministration with other CNS depressants.sufentanil SL, flibanserin. sufentanil SL and pills to increase sex drive male flibanserin both increase sedation.
Consumer Information Use and Disclaimer
sulconazolesulconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sulconazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tacrolimustacrolimus will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tacrolimus will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. talazoparibflibanserin increases levels of talazoparib by P-glycoprotein (MDR1) efflux transporter.
Addyi (filbanserin)
Coadministration with P-gp inhibitors may increase talazoparib exposure. Monitor for increased talazoparib adverse reactions and adjust dose as necessary. flibanserin increases levels of talazoparib by P-glycoprotein (MDR1) efflux transporter. tamoxifentamoxifen will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tamoxifen will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vincristine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vincristine liposomal will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vinorelbinevinorelbine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Flibanserin is used to treat premenopausal women with hypoactive sexual desire disorder (HSDD).
- It is marketed under the brand name Addyi.
- Flibanserin works by modulating serotonin and dopamine levels in the brain.
- It was approved by the FDA in 2015 for HSDD treatment.
- Common side effects include dizziness, nausea, and fatigue.
- Flibanserin is usually taken once daily at bedtime.
- It has contraindications with alcohol due to risk of severe hypotension.
- Patients should avoid alcohol while using flibanserin.
- It is a non-hormonal medication specifically for sexual desire issues.
vinorelbine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Feature | Flibanserin | Bremelanotide | Vyleesi |
|---|---|---|---|
| Approved for HSDD | Yes | No | Yes |
| Administration Route | Oral | Injectable | Injectable |
| Usage Frequency | Daily | As needed | As needed |
| Main Side Effects | Dizziness, nausea | Nausea, flushing | Nausea, reactions at injection site |
zafirlukastzafirlukast will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
| Condition | Reason |
|---|---|
| Alcohol Use | Increased sedation & hypotension |
| CYP3A4 Inhibitors | Elevated flibanserin levels |
| Liver impairment | Reduced metabolism & clearance |
| Hypotension | Risk of further blood pressure drop |
zafirlukast will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Warnings & Precautions
tecovirimattecovirimat will increase the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. Monitor for adverse effects if coadministered with sensitive substrates of these enzymes.tecovirimat will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. tecovirimat will increase the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. Monitor for adverse effects if coadministered with sensitive substrates of these enzymes.
Pharmacogenetic associations and support therapeutic management recommendations
temsirolimustemsirolimus will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. temsirolimus will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. teniposideteniposide will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. teniposide will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. testosteronetestosterone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Are you currently using Addyi (flibanserin)?
testosterone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. testosterone topical will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tranylcyprominetranylcypromine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tranylcypromine will increase the level or effect of flibanserin by vardenafil 5 mg affecting hepatic/intestinal enzyme CYP3A4 metabolism. trazodonetrazodone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ziprasidoneziprasidone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Flibanserin's side effects need to be balanced against its benefits.
- It is not recommended for use in women who are pregnant or planning pregnancy.
- The medication's pharmacodynamics involve complex neurotransmitter interactions.
- Some women may experience relapse of symptoms after discontinuation.
- The drug must be prescribed with appropriate patient counseling regarding risks.
- Its approval sparked discussions about gender disparities in drug development.
- Flibanserin’s impact on sexual desire has led to increased research interest.
- Proper patient selection is critical for optimal outcomes.
- It represents one of the few pharmacological options for HSDD.
Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.flibanserin, ziprasidone.
Why is this medication prescribed?
trazodone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. triclabendazoletriclabendazole will increase the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. If plasma concentrations of the CYP2C19 substrates are elevated during triclabendazole, recheck plasma concentration of the CYP2C19 substrates after discontinuation of triclabendazole. triclabendazole will increase the level or effect of flibanserin by affecting hepatic enzyme CYP2C19 metabolism. valproic acidvalproic acid will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ziprasidone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
- Flibanserin acts as an agonist on dopamine receptors and antagonist on certain serotonin receptors.
- The medication can take several weeks to show benefits.
- It is not approved for use in postmenopausal women.
- Flibanserin was initially developed as an antidepressant.
- It has a pharmacokinetic profile with a half-life of around 13 hours.
- Dose adjustments are necessary for patients with liver impairment.
- The drug can cause hypotension, especially with alcohol or CYP3A4 inhibitors.
- Patients are monitored for side effects such as sleepiness and low blood pressure.
- Flibanserin's efficacy is moderate and varies among women.
acetazolamideacetazolamide will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. acetazolamide will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. anastrozoleanastrozole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What SIDE EFFECTS can this medicine cause?
rabeprazolerabeprazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rabeprazole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ranolazineranolazine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ranolazine will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifabutin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What should I do if I accidentally use too much Addyi?
rifampinrifampin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifampin will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifapentinerifapentine will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifapentine will decrease the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. risperidonerisperidone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Breast Feeding
Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.flibanserin, risperidone. risperidone will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rucaparibrucaparib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rucaparib will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. scopolamine intranasalscopolamine intranasal and flibanserin both increase sedation. anastrozole will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism.